柏草洗剂联合米诺地尔治疗不同年龄段雄激素性脱发的疗效对比

Efficacy comparison of Baicao lotion combined with minoxidil in treating androgenetic alopecia across age groups

摘要:

目的观察柏草洗剂联合米诺地尔治疗不同年龄段雄激素性脱发的疗效差异。 方法纳入上海市皮肤病医院毛发诊疗中心2024年1—6月就诊的94例雄激素性脱发患者。按年龄分为青年组(≤34岁，34例)、中年组(35~44岁，26例)、老年组(≥45岁，34例)。每组随机分配至对照组(5%米诺地尔)或治疗组(柏草洗剂+5%米诺地尔)，比较各组愈显率、总有效率、毛发密度及不良反应。 结果各年龄段联合治疗组临床疗效均显著优于单药对照组，但疗效随年龄增长呈梯度递减趋势。青年组联合治疗总有效率为94.1%，较单药组的82.4%显著提高。中年组联合治疗总有效率为92.3%，显著高于单药组(76.9%)。老年组联合治疗总有效率为66.5%，高于单药组(58.8%)，但差距缩小。毛发密度改善同样呈现年龄依赖性，青年组增幅最大，中年组次之，老年组最小，组间差异有统计学意义(P<0.05)。安全性方面，各年龄段不良反应率差异无统计学意义(P>0.05)，青年组以轻度瘙痒为主(11.8%)，中年组多见药物性皮炎(15.4%)，老年组主要表现为局部红斑(11.8%)，均未发生严重不良事件。 结论柏草洗剂联合5%米诺地尔治疗雄激素性脱发的疗效随年龄增长递减，其中青年患者获益最显著，且各年龄段均安全性良好。

Abstract:

ObjectiveTo evaluate the efficacy of Baicao lotion(BL) combined with minoxidil in treating androgenetic alopecia(AGA) across age groups. MethodsA total of 94 patients with AGA treated at the Hair Diagnosis and Treatment Center of Shanghai Skin Disease Hospital from January to June in 2024 were included. The patients were divided by age into a youth group(≤34 years, 34 cases), a middle-aged group(35-44 years, 26 cases), and an elderly group(≥45 years, 34 cases). Each group was randomly assigned to either a control group(5% minoxidil) or a treatment group(BL+5% minoxidil). The marked effectiveness rate, total effectiveness rate, hair density, and adverse reactions were compared among the groups. ResultsCombination therapy demonstrated superior efficacy to monotherapy across all age groups, though with a declining benefit gradient with advancing age: the overall response rate was 94.1% versus 82.4% in youth, 92.3% versus 76.9% in middle-aged, and 66.5% versus 58.8% in elderly patients. Hair density improvement showed age-dependent effects, with the most significant increase in youth and the least in elderly groups(P<0.05). Safety profiles were comparable across age groups(P>0.05), with mild pruritus(11.8%) mainly in youth, drug-induced dermatitis(15.4%) in middle-aged, and local erythema(11.8%) in elderly patients. No serious adverse events occurred. ConclusionThe efficacy of Baicao lotion combined with 5% minoxidil in treating AGA decreases with age, with the most significant benefit observed in the youth, and it demonstrates good safety across all age groups.