上海市某区老年社区居民ALT与营养代谢指标的相关性研究

Association between alanine aminotransferase levels and nutritional and metabolic factors in elderly community residents in a district of Shanghai

摘要:

目的分析老年人丙氨酸氨基转移酶(alanine amino-transferase, ALT)与各营养代谢指标之间的关系，并探索其影响因素。 方法选取2023年2月—2023年10月上海市宝山区某社区9565名年龄≥65岁的老年体检者作为研究对象。收集研究对象的基本情况、体格测量及实验室生化检测指标等数据。依据中国ALT参考标准，将老年体检者分为ALT正常组与ALT异常组。对比两组的体格测量指标及营养代谢指标水平，进行相关性分析，并分析ALT异常的危险因素。 结果与ALT异常组相比，ALT正常组年龄、身高、体重、体重指数(body mass index, BMI)、腰围(waist circumference, WC)、总胆固醇(total cholesterol, TC)、血红蛋白(hemoglobin, Hb)、高密度脂蛋白(high-density lipoprotein, HDL)、低密度脂蛋白(low-density lipoprotein, LDL)等指标差异有统计学意义(P＜0.05)。身高、体重、WC、臀围(hip circumference, HC)、收缩压(systolic blood pressure, SBP)、舒张压(diastolic blood pressure, DBP)、Hb与ALT水平呈正相关(P＜0.05)，HDL与ALT水平呈负相关(P＜0.05)。Logistic回归分析显示，BMI、Hb是ALT异常的危险因素(P＜0.05)，而较高的身高、年龄及HDL水平是ALT异常的保护因素(P＜0.05)。 结论定期筛查社区老年人的ALT及营养代谢指标，可为评估老年人健康状况提供关键信息，有助于制定针对性措施改善其健康与营养状况，提升生活质量。

Abstract:

ObjectiveTo analyze the associations between alanine aminotransferase(ALT) levels and nutritional metabolism indicators in older adults and identify their influencing factors. MethodsA total of 9565 community residents aged ≥65 years from Baoshan District, Shanghai, were enrolled between February and October in 2023. The data on demographics, anthropometric measurements including age, height, weight, body mass index(BMI) and waist circumference, as well as serum biochemical indices such as total cholesterol(TC), hemoglobin(Hb), high-density lipoprotein(HDL) and low-density lipoprotein(LDL) were collected. Based on Chinese reference standards, the participants were classified into normal and abnormal ALT groups. The anthropometric and metabolic parameters were compared between the two groups, correlation analysis was performed and the risk factors for abnormal ALT were analyzed. ResultsThere were statistically significant differences in indicators such as age, height, weight, body mass index(BMI), waist circumference(WC), total cholesterol(TC), hemoglobin(Hb), high-density lipoprotein(HDL), and low-density lipoprotein(LDL) between the two groups(all P<0.05). Height, weight, waist circumference(WC), hip circumference(HC), systolic blood pressure(SBP), diastolic blood pressure(DBP), and hemoglobin(Hb) were positively correlated withALT levels(all P<0.05); while HDL was negatively correlated with ALT levels,(P<0.05). The Logistic regression analysis showed that high BMI and high Hb were risk factors for abnormal alanine aminotransferase(ALT)(both P<0.05), whereas higher height, age, andHDL levels were protective factors for abnormal ALT(all P<0.05). ConclusionRegular screening of ALT and nutritional metabolism indicators in older adults can provide crucial information for health assessment and facilitate the development of targeted interventions to optimize nutritional status, and ultimately enhance the quality of life of the elderly population.