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堵翠,黄东雅.核仁转录体系在DNA损伤诱导神经毒性中的作用[J].同济大学学报（医学版）,2012,33(3):117-120. [点击复制]
- DU Cui,HUANG Dong-ya.Nucleolar transcriptional machinery is involved in DNA damage-induced Neurotoxicity[J].Journal of Tongji University(Medical Science),2012,33(3):117-120. [点击复制]
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| 核仁转录体系在DNA损伤诱导神经毒性中的作用 |
| 堵翠,黄东雅 |
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| (同济大学附属东方医院神经内科,上海 200120) |
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| 摘要: |
| 实验与临床研究证明DNA损伤诱导的神经毒性参与多种神经系统退行性疾病的发生发展过程。核仁转录体系作为基因组完整性的理想监测位点,可通过影响核糖体的合成及与其他信号因子的相互作用,参与DNA损伤诱导的神经元凋亡及慢性神经毒性。本研究将围绕这一观点的相关研究进行综述。 |
| 关键词: DNA损伤 凋亡 转录 RNA聚合酶1(RNAPoll) |
| DOI：10.3969/j.issn1008-0392.2012.03.029 |
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| 基金项目:上海市浦东新区科委项目（PKJ2009-Y17) |
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| Nucleolar transcriptional machinery is involved in DNA damage-induced Neurotoxicity |
| DU Cui,HUANG Dong-ya |
| (Dept.of Neurology,East Hospital,Tongji University,Shanghai 200120,China) |
| Abstract: |
| Clinical and experimental researches have demonstrated that DNA damage-induced neurotoxicity is involved in the onset and progress of many neurodegenerative diseases.Recent studies have discovered that RNA polymerase 1 transcriptional machinery,as a candidate for genome integrity checkpoint,plays an important role in DNA damage-induced apoptosis and chronic disruption of neurons by affecting the synthesis of ribosomes and interacting with other signal molecules. |
| Key words: DNA damage apoptosis transcription RNA Polymerase 1(RNAPoll) |
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