肥胖者血清成纤维细胞生长因子21的水平及其临床意义

Serum FGF21 levels in obese subjects and its clinical significance

关键词:  成纤维细胞生长因子21  肥胖  2型糖尿病  代谢综合征

Key words:  fibroblast growth factor 21  obesity  type 2 diabetes meUitus  metabolic syndrome

摘要:

目的探讨肥胖者血清成纤维细胞生长因子21（fibroblast growth factor 21,FGF21）水平及其临床意义。方法选取50例肥胖患者（BMI≥28 kg/m2）为试验组,同期行健康体检正常的志愿者（BMI〈24 kg/m2）50例为对照组。记录受试者的身高、体质量、血压、腰围、臀围,计算腰臀比、体质量指数,检测血脂、超敏C反应蛋白、空腹血糖、胰岛素、糖化血红蛋白等指标,并采用酶联免疫吸附法检测血清FGF21的表达。结果肥胖组FGF-21的水平明显高于对照组,差异有统计学意义（P〈0.05）;FGF21与腰围、腰臀比（waist-to-hip ratio,WHR）、空腹血浆葡萄糖（fasting plasma glucose,FPG）、HbA1c、空腹血清胰岛素（fasting insulin,FINS）、三酰甘油（TG）、超敏C反应蛋白（hsCRP）呈正相关,与高密度脂蛋白胆固醇（HDL-C）呈负相关（P〈0.05）;多元线性回归结果显示,肥胖、血糖升高和三酰甘油升高是FGF21表达增加的独立危险因素。结论FGF21有可能成为代谢综合征的预测因子。

Abstract:

Objective To investigate serum fibroblast growth factor 21 （FGF-21） levels in obese subjects and its clinical significance. Methods Fifty obese subjects （BMI ≥28 kg/m2） and fifty normal controls（BMI 〈 24 kg/m2） were recruited. Fasting serum FGF-21 levels were measured with enzyme-linked immunosorbent assay. The anthropometric parameters, glucose, lipids, insulin and high sensitive C-reactive protein （hs-CRP） levels were also measured. Results Serum FGF-21 levels were significantly higher in obese subjects than those in controls （P〈0.05 ）. Fasting serum FGF-21 was positively correlated with waist circumference, waist-to-hip ratio （WHR）, fasting plasma glucose （ FPG）, HbAlc, fasting insulin （FINS）, triglyceride （TG） and hs-CRP; negatively correlated with high-density lipoprotein in cholesterol （HDL-C）. Multivariate linear regression analysis showed that increased waist circumference, elevated FPG and triglycerides were independent risk factors for increased serum FGF-21. Conclusion Serum FGF-21 level may be of value in prediction of metabolic syndrome.