CHEN Li,WANG Zhi-rong,LI Xiao-gang.Comparison of detection rate of peptic ulcer in patients with positive or negative hepatitis B surface antigen[J].Journal of Tongji University(Medical Science),2016,37(4):74-77. [点击复制]
ObjectiveTo compare the detection rate of peptic ulcer in chronic hepatitis B patients with positive or negative hepatitis B surface antigen(HBsAg). Methods Total 2932 patients with chronic HBV infection admitted in our hospital from May 2013 to May 2015 were enrolled, including 2660 cases with negative HBsAg(negative group) and 272 cases with positive HBsAg(positive group). The prevalence of peptic ulcer and Helicobacter pylori (HP) infection were compared between two groups. Results There were 62 cases of peptic ulcers in HBsAg positive group, including 30 cases of gastric ulcer, 18 cases of duodenal ulcer and 14 cases of compound ulcer with a prevalence rate of 22.8%. There were 294 cases of peptic ulcer in HBsAg negative group, including 71 cases of gastric ulcer, 47 cases of duodenal ulcer and 176 cases of combined ulcer with a prevalence rate of 11.1%. The prevalence of peptic ulcer in HBsAg positive group was significantly higher than that in negative group(P<0.05). In HBsAg positive group, the prevalence of peptic ulcer in males were higher than that in females(16.54% vs 28.28%, P<0.05); while in HBsAg negative group, there was no significant differences in prevalence rate of peptic ulcer between male and female patients(11.41% vs 10.67%, P>0.05). HP positive rate in HBsAg positive group was significantly higher than that in HBsAg negative group(72.06% vs 58.08%, P<0.05). Conclusion Chronic hepatitis B patients with positive HBsAg are likely to have peptic ulcer and HP infection, particularly for male patients.
