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虞宇楠,古扎努尔·阿不都合里力,叶梓,等.急性肺栓塞患者血流动力学和血栓形态学特征[J].同济大学学报（医学版）,2022,43(3):355-360. [点击复制]
- YU Yunan,Guzhanuer Abuduhelili,YE Zi,et al.Hemodynamic characteristics and thrombus morphology in patients with acute pulmonary embolism[J].Journal of Tongji University(Medical Science),2022,43(3):355-360. [点击复制]
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| 急性肺栓塞患者血流动力学和血栓形态学特征 |
| 虞宇楠,古扎努尔·阿不都合里力,叶梓,陈发东 |
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| (同济大学附属同济医院心血管内科，上海200065) |
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| 摘要: |
| 目的总结和分析急性肺栓塞患者的血流动力学和血栓形态学特征。方法回顾性分析单中心43例急性肺栓塞患者的临床特征、危险因素、治疗方法、右心导管检查和肺动脉造影结果，分析右心功能、肺动脉压力水平、血栓的分布和形态学特征。结果43例急性肺栓塞患者中，男21例，女22例，年龄（66.4±10.9）岁。合并慢性血栓患者16例。肺栓塞合并慢性血栓患者平均肺动脉压力(P=0.04)、肺血管阻力水平(P=0.02)均显著高于单纯肺栓塞患者，且肺动脉压力升高在PE伴慢性血栓患者发生率显著高于单纯PE患者(P=0.03)。结论部分急性肺栓塞患者可出现慢性血栓征象，且多数伴肺动脉压力升高，可能是发展为慢性血栓栓塞性疾病或慢性血栓栓塞性肺动脉高压的高危人群，须加强对此类患者的治疗及随访。 |
| 关键词: 肺栓塞 慢性血栓 血流动力学 血栓形态学 |
| DOI：10.12289/j.issn.1008-0392.22054 |
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| 投稿时间：2022-02-13 |
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| 基金项目:上海市自然科学基金（19XD1403300） |
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| Hemodynamic characteristics and thrombus morphology in patients with acute pulmonary embolism |
| YU Yunan,Guzhanuer Abuduhelili,YE Zi,CHEN Fadong |
| (Department. of Cardiology, Tongji Hospital, School of Medicine, Tongji University, Shanghai 200065, China) |
| Abstract: |
| ObjectiveTo analyze the hemodynamic characteristics and thrombus morphology in patients with acute pulmonary embolism. MethodsThe medical records of 43 patients aged （66.4±10.9） years with acute pulmonary embolism, including clinical features, risk factors, right heart catheterization and pulmonary angiography results were retrospectively analyzed. ResultsThe signs of chronic thrombosis were present in 16 patients. The levels of mean pulmonary artery pressure (P=0.04) and pulmonary vascular resistance (P=0.02) were significantly higher in patients with chronic thrombosis than those in patients with isolated pulmonary embolism. ConclusionPatients with acute pulmonary embolism may present chronic thrombosis signs and elevated pulmonary artery pressure. Adequate anticoagulant therapy and long-term follow-up were strongly recommended in those high-risk patients for chronic thromboembolic disease or chronic thromboembolic pulmonary hypertension. |
| Key words: pulmonary embolism chronic thrombosis hemodynamics thrombus morphology |
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