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林浩,袁得强,陈飞,等.SGLT2抑制剂在冠心病中的作用机制的研究进展[J].同济大学学报（医学版）,2023,44(6):925-932. [点击复制]
- LIN Hao,YUAN Deqiang,CHEN Fei,et al.Research progress on pharmacological effects and relevant mechanism of SGLT2 inhibitors in coronary heart disease[J].Journal of Tongji University(Medical Science),2023,44(6):925-932. [点击复制]
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| SGLT2抑制剂在冠心病中的作用机制的研究进展 |
| 林浩,袁得强,陈飞,刘学波 |
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| (同济大学医学院，上海 200092;同济大学附属同济医院心血管内科，上海 200065) |
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| 摘要: |
| 钠-葡萄糖协同转运蛋白2抑制剂（sodium-dependent glucose transporters 2 inhibitors, SGLT2i）被广泛应用于降糖治疗，并且已被推荐为Ⅰ类药物治疗心力衰竭。然而，SGLT2i在冠心病中的作用和机制尚无准确定论。本文概述了SGLT2i在冠心病中的药理作用和相关机制，特别是其改善血管内皮功能的作用；同时讨论了相关研究的局限性和未来的研究方向。该综述对SGLT2i在冠心病中的研究提供了新的思路和参考，对于临床应用和科研方向具有重要意义。 |
| 关键词: SGLT2抑制剂 冠状动脉粥样硬化性心脏病 内皮功能 |
| DOI：10.12289/j.issn.1008-0392.23034 |
| 通信作者: |
| 投稿时间：2023-02-04 |
| 录用日期： |
| 基金项目:国家自然科学基金（82170346）；上海市科学技术委员会优秀学术带头人项目（19XD1403300）；上海市科学技术委员会科研计划项目（22Y11909800）；上海卫生健康委员会医学领军人才计划项目（2019LJ10） |
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| Research progress on pharmacological effects and relevant mechanism of SGLT2 inhibitors in coronary heart disease |
| LIN Hao,YUAN Deqiang,CHEN Fei,LIU Xuebo |
| (School of Medicine, Tongji University, Shanghai 200092, China; Department of Cardiology, Tongji Hospital, School of Medicine, Tongji University, Shanghai 200065, China) |
| Abstract: |
| Sodium-dependent glucose transporter 2 inhibitors(SGLT2i) have been widely used for glucose-lowering therapy andalso recommended as a class Ⅰ medication for treating heart failure. However, the exact effects and mechanisms of SGLT2i in coronary heart disease(CHD) are still not fully understood. This review summarizes the pharmacological effects and relevant mechanisms of SGLT2i in CHD, particularly for improving vascular endothelial function; and also discusses limitations of related studies and future research directions. |
| Key words: SGLT2 inhibitors coronary atherosclerosis heart disease endothelial function |
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