粪菌移植治疗炎症性肠病躯体-心理症状的研究进展

Progress on fecal microbiota transplantation for treatment of phychosomatic symptoms in inflammatory bowel disease

关键词:  炎症性肠病  情绪障碍  脑-肠轴  粪菌移植

Key words:  inflammatory bowel disease  mental disorder  brain-gut axis  fecal microbiota transplantation

摘要:

炎症性肠病是一种由免疫介导的慢性非特异性肠道炎性疾病。近年来，其发病率在中国呈显著上升趋势。目前诸多研究发现炎症性肠病不仅影响消化系统的正常功能，还会通过微生物群-肠-脑轴影响患者的情绪和行为功能。其中，焦虑和抑郁等心理合并症对患者的影响更为突出。同时肠道-心理的交互作用还会影响患者的自然病程，增加疾病出现不良结局的风险。因此在治疗炎症性肠病躯体症状的同时，心理干预及治疗已逐渐引起研究者的重视。目前，粪菌移植治疗作为依赖于该轴的新兴治疗策略逐渐受到关注。本文就炎症性肠病躯体-心理症状的相互作用以及粪菌移植治疗在炎症性肠病躯体-心理症状治疗中的应用前景予以综述。

Abstract:

Inflammatory bowel disease(IBD) is a chronic non-specific intestinal inflammatory disorder mediated by immunity disturbance with increasing incidence recently. Studies have shown that IBD not only affects the normal functions of the digestive system but also has an impact on mental and behavioral functions of patients through the microbiota-gut-brain axis. Psychological comorbidities such as anxiety and depression have a particularly prominent effect on IBD patients. Additionally, the interactions between the gut and psychological factors can also influence the natural course of the disease and increase the risk of adverse outcomes. Therefore, alongside the treatment of the physical symptoms of IBD, the psychological interventions have received more and more attentions. Fecal microbiota transplantation therapy has been emerged as a treatment strategy based on the concept of microbiota-gut-brain axis. This article provides a review of the interaction between the physical and psychological symptoms of IBD and explores the potential application of fecal microbiota transplantation in treatment of phychosomatic symptoms in IBD.