PGC-1α在骨代谢中的作用

The role of PGC-1α in bone metabolism

摘要:

过氧化物酶体增殖物激活受体γ共激活因子-1α（peroxisome-proliferator-activated receptor γ coactivator-1α, PGC-1α）在多种脏器的氧化代谢及线粒体氧化应激过程中发挥着重要作用。同时在骨代谢中，PGC-1α能够促进成骨细胞的增殖、分化以及矿化，抑制破骨细胞的生成，维持骨细胞特异基因的表达。本文将从PGC-1α在成骨细胞、骨细胞以及破骨细胞中的作用三个方面进行综述，以期为骨骼代谢相关疾病的机制和诊治过程提供新的思考方向。

Abstract:

Peroxisome-proliferator-activated receptor γ coactivator-1α（PGC-1α) is a master regulator of oxidative metabolism and mitochondrial oxidative stress in various organs. In bone metabolism, PGC-1α promotes the differentiation, proliferation and mineralization of osteoblasts and inhibits the differentiation of osteoclasts. At the same time, it is important for maintaining the expression of specific genes in osteocytes. This article reviews the effects of PGC-1α on osteoblasts, osteocytes and osteoclasts to provide insight for the mechanism, diagnosis and treatment of bone metabolism-related diseases.