2型糖尿病合并颈动脉粥样硬化与血清脂联素、瘦素的相关性

Association between type 2 diabetes mellitus complicated with carotid atherosclerosis and serum adiponectin and leptin

摘要:

目的研究血清脂联素、瘦素的表达与2型糖尿病(type2 diabetes mellitus, T2DM)合并颈动脉粥样硬化(carotid atherosclerosis, CAS)的相关性。 方法选择2022年8月—2024年8月在上海市金山区亭林医院就诊的T2DM患者作为研究对象(n=110)，根据颈动脉超声检查结果，再分为T2DM组(n=53)和T2DM+CAS组(n=57)；选择同期在我院体检的同年龄段健康人群作为对照组(n=50)。分别收集各组的临床资料及生化指标，包括空腹静脉血浆葡萄糖(fasting plasma glucose, FPG)、糖化血红蛋白(hemoglobin A1c, HbA1c)、甘油三酯(triglyceride, TG)、高密度脂蛋白胆固醇(high-density lipoprotein cholesterol, HDL-C)、超敏C反应蛋白(high-sensitivity C-reactive protein, hs-CRP)等，采用ELISA法检测血清脂联素、瘦素的水平，对各种检测数据进行相关统计学分析。 结果与对照组相比，T2DM组和T2DM+CAS组患者血清FPG、HbA1c、hs-CRP、瘦素水平升高(P<0.05)，血清脂联素水平降低(P<0.05)。在T2DM+CAS组中，血清瘦素水平与FPG、GHbA1c、TG、hs-CRP呈正相关(P<0.05)，与HDL-C呈负相关(P<0.05)；血清脂联素水平与HDL-C呈正相关(P<0.05)，与FPG、GHbA1c、TG、hs-CRP、瘦素呈负相关(P<0.05)。 结论在T2DM合并CAS患者中，血清脂联素表达下调，血清瘦素表达上调，两者与T2DM合并CAS有相关性。临床检测血清脂联素、瘦素水平可能对T2DM合并动脉粥样硬化具有预测价值。

Abstract:

ObjectiveTo investigate the correlation between serum adiponectin/leptin expression and type 2 diabetes mellitus (T2DM) complicated with carotid atherosclerosis (CAS). MethodsA total of 110 T2DM patients treated in Shanghai Jinshan Tinglin Hospital from August 2022 to August 2024 were enrolled as study subjects. Based on carotid ultrasound results, the patients were further divided into T2DM group(n=53) and T2DM+CAS group(n=57). Additionally, 50 healthy individuals of the same age range who underwent physical examinations in Tinglin Hospital during the same period were enrolled as the control group(n=50). The clinical data and biochemical parameters were collected, including fasting plasma glucose(FPG), hemoglobin A1c(HbA1c), triglyceride(TG)、high-density lipoprotein cholesterol(HDL-C), high-sensitivity C-reactive protein(hs-CRP), et al. Serum adiponectin and leptin levels were measured by using ELISA methods, and the various detected data were performed relevant statistical analysis. ResultsCompared with the control group, the serum FPG, GHbA1c, hs-CRP and leptin levels were significantly higher, while serum adiponectin levels were significantly lower in T2DM and T2DM+CAS groups(all P<0.05). In T2DM+CAS group, serum leptin level was positively correlated with FPG, GHbA1c, TG and hs-CRP(all P<0.05), while negatively correlated with HDL-C(P<0.05). Serum adiponectin level was positively correlated with HDL-C(P<0.05), while negatively correlated with FPG, GHbA1c, TG, hs-CRP and leptin(all P<0.05). ConclusionIn T2DM patients complicated with CAS, serum adiponectin expression is downregulated, while serum leptin expression is upregulated, and both are correlated with the condition of T2DM complicated with CAS. Clinical detection of serum adiponectin and leptin levels may have predictive value for T2DM complicated with atherosclerosis.