| 摘要: |
| 目的：探讨活性依赖性神经保护蛋白（activity-dependent neuroprotective protein,ADNP)同源基因的表达与阿尔茨海默病的关系。方法：采用淀粉样β-肽注射大鼠脑室，制备阿尔茨海默病样损伤大鼠模型，15d后通过RT－PCR方法检测大鼠脑海马胆碱乙酰转移酶（choline acetyltransferase,ChAT)基因，活性依赖性神经保护蛋白基因及Mn-SOD,Cu,Zn-SOD基因的表达。结果：胆碱乙酰转移酶，ADNP基因的表达在实验组海马中均下降，Cu,Zn,-SOD基因的表达没有明显变化，而Mn-SOD则有所升高。结论：结果提示ADNP表达降低，使神经细胞缺乏保护因素，与阿尔茨海默病的发生发展相关。 |
| 关键词: 活性依赖性神经保护蛋白 基因表达 阿尔茨海默病 大鼠 |
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| 基金项目:铁道部科技基金资助项目(B9979) |
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| The Expression of Activity-dependent Neuroprotective Protein Homogenetic Gene inRat Hippocampus of Alzheimer''''s Model |
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| Abstract: |
| Objective To investigate the interrelation of the expression of activity-dependent neuroprotective protein (ADNP) homogenetic gene and Alzheimer's disease.(AD).Methods The rat models of Alzheimer's disease were prepared with infusion of amyloid beta-pep |
| Key words: activity-dependent neuroprotective protein,gene expression,Alzheimer's disease,rat |
