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许树长,张志强,陈锡美,叶元康,王炳芳,张东伟.反流性食管炎患者的幽门螺杆菌感染[J].同济大学学报(医学版),2005,(5):45-48. [点击复制]
- .Role of Helicobacter pylori Infection in Patients with Reflux Esophagitis[J].Journal of Tongji University(Medical Science),2005,(5):45-48. [点击复制]
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摘要: |
目的探讨幽门螺杆菌在反流性食管炎发病中的作用.方法选择有典型反流症状的患者并经胃镜检查诊断为反流性食管炎53例作为病例组,无典型反流症状的患者并经胃镜检查诊断为慢性胃炎25例作为对照组,分别取食管下端黏膜及胃窦黏膜各3块,并分别行快速尿素酶试验、病理Hp检查和Hp培养,食管及胃窦黏膜Hp菌株应用PCR方法行cagA基因、vacA基因检测.结果病例组、对照组中食管黏膜的Hp阳性率分别为14/53(26.4%)、8/25(32%),两者差异无显著性(P>0.05);胃窦黏膜的Hp阳性率分别为20/53(37.8%)、16/25(64%),两者差异有显著性(P<0.05);病例组中胃窦黏膜Hp的cagA+检出率(6/20,30%)明显低于对照组(10/16,62.5%)(P<0.05),而vacA+检出率分别为6/20(30%)、7/16(43.8%),两者差异无显著性(P>0.05).不同程度食管炎中食管黏膜Hp阳性率差异无显著性(P>0.05),胃窦黏膜Hp阳性率差异有显著性(P<0.01),而cagA+及vacA+的Hp菌株的差异无显著性(P>0.05),但cagA+菌株多见于程度轻的食管炎.结论食管黏膜中检测到的Hp可能来源于胃窦黏膜的Hp,胃窦Hp感染、尤其是cagA+的Hp感染可能在RE的发生中有一定的保护作用. |
关键词: 反流性食管炎 幽门螺杆菌 cagA基因 vacA基因 |
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修订日期:2005-05-24 |
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Role of Helicobacter pylori Infection in Patients with Reflux Esophagitis |
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Abstract: |
Objective To investigate the role of Helicobacter pylori (H. pylori) infection in patients with reflux esophagitis(RE). Methods A total of 53 patients with RE,having typical reflux symptoms and diagnosed by endoscopy, were studied. 25 patients presenting |
Key words: reflux esophagitis Helicobacter pylori cagA gene vacA gene |