| 引用本文： |
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朱风尚,陈锡美,张东伟,王志荣,张霞.埃索美拉唑为基础的三联疗法治疗Hp阳性十二指肠溃疡临床研究[J].同济大学学报（医学版）,2006,(4):50-53. [点击复制]
- .Clinical Study of Two Differential Esomeprazole-based One-week Triple Therapy Regimens for Duodenal Ulcer with Helicobacter pylori Infection[J].Journal of Tongji University(Medical Science),2006,(4):50-53. [点击复制]
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| 摘要: |
| 目的比较埃索美拉唑为基础的二种三联疗法治疗幽门螺杆菌(Helicobacter pylori,Hp或H.pylori)阳性十二指肠球部溃疡临床疗效、耐受性、依从性和不良反应。方法采用前瞻、随机对照研究,将94例Hp阳性十二指肠球部溃疡患者随机分为2组。EAC组(46例):埃索美拉唑20 mg 阿莫西林1 g 克拉霉素500 mg;EFA组(48例):埃索美拉唑20 mg 呋喃唑酮0.1 g 阿莫西林1 g,均每日2次,共7 d。停药4周后复查内镜并检测Hp,观察临床疗效、耐受性、依从性和不良反应。结果共有94例患者入选,4例患者退出。按符合方案集(per-protocol,PP)分析,EAC组和EFA组临床症状缓解率分别为:上腹痛100%vs.100%、反酸90.9%vs.91.7%、烧心93.8%vs.95%(P均>0.05)。镜下溃疡愈合率分别为95.5%和93.5%,Hp根除率分别为90.9%和100%,2年内溃疡复发率分别为7.5%和5.0%(P均>0.05)。两组药物耐受性、依从性良好;不良反应发生率较低且无差异(P>0.05)。结论对Hp阳性十二指肠溃疡,埃索美拉唑为基础二种三联疗法临床疗效、耐受性、依从性和不良反应等方面无明显差异,均为较好的治疗方案。 |
| 关键词: 埃索美拉唑,幽门螺杆菌,十二指肠溃疡,三联疗法 |
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| 修订日期：2006-05-11 |
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| Clinical Study of Two Differential Esomeprazole-based One-week Triple Therapy Regimens for Duodenal Ulcer with Helicobacter pylori Infection |
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| Abstract: |
| Objective To evaluate the efficacy,tolerability,drug compliance and adverse effects of two differential esomeprazole-based one-week triple therapy regimens for duodenal ulcer(DU) with Helicobacter pylori infection.Methods A prospective,randomized positive |
| Key words: esomeprazole,Helicobacter pylori,duodenal ulcer,triple therapy |
