2型糖尿病与高龄老人良性前列腺增生症的关系研究

Relationship between type 2 diabetes mellitus and benign prostatic hyperplasia in elderly patients

关键词:  良性前列腺增生  2型糖尿病  糖化血红蛋白  老年人

Key words:  benign prostatic hyperplasia  type 2 diabetes mellitus  glycated hemoglobin  elderly

摘要:

目的探讨2型糖尿病(T2DM)与高龄老年人良性前列腺增生症(bengn prostatic hyperplasia,BPH)的关系。方法回顾性分析167例高龄BPH患者的临床资料,其中单纯BPH患者64例,T2DM合并BPH患者103例。收集血压、空腹血糖(FBG)、餐后2 h血糖(2 h PBG)、空腹胰岛素(FINS)、糖化血红蛋白(HbAlc)、血脂、血清前列腺特异性抗原(PSA)、国际前列腺症状评分(IPSS)及经腹部超声测量的前列腺体积(PV)等临床资料。结果单纯BPH组和T2DM合并BPH组,两组年龄、合并高血压及高脂血症情况比较,差异无统计学意义(P＞0.05);与单纯BPH组相比,BPH合并T2DM组患者血清FINS、PSA、PV水平及IPSS评分显著升高(P＜0.05)。BPH合并T2DM组中,不同水平FBG、2 h PBG患者的IPSS评分、PV与血清PSA,差异无统计学意义(P＞0.05);BPH合并T2DM组中,HbA1c升高患者与HbA1c正常者比较,IPSS评分、PV与血清PSA明显升高(P＜0.05)。结论T2DM是高龄患者BPH发生与进展的危险因素。

Abstract:

Objective To investigate the relationship between (BPH) and type 2 diabetes mellitus (T2DM ) in elderly patients. Methods A total of 167 elderly BPH patients were recruited, including 64 cases of non-diabetic BPH and 103 cases of diabetic BPH. The blood pressure and international prostate symptoms score (IPSS) were documented; the prostate volume (PV) was examined by ultrasonography. Glycated hemoglobin ( HbA1C )，FBG，FINS，blood lipid and serum prostate specific antigen (PSA) were measured. Results There were no differences in age, prevalence of hypertension and hyperlipidemia between non-diabetic BPH and diabetic BPH patients (P＞0.05) . The serum levels of FINS and PSA, PV and IPSS in diabetic BPH patients were higher than those in non-diabetic BPH patients (P＜0.05) . There were no differences in IPSS, PV and PSA at the different levels of FBG and 2 h PBG in diabetic BPH patients (P＞0.05) . The level of IPSS, PV and serum PSA in diabetic BPH patients with abnormal HbAlc were higher than those in BPH patients with normal HbAlc (P＜0.05). Conclusion T2DM might be a risk factor for the onset and development of BPH in elderly patients.