| 引用本文： |
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杨社珍,方红贤.厄贝沙坦治疗早期糖尿病肾病疗效分析[J].同济大学学报（医学版）,2013,34(5):98-101. [点击复制]
- YANG She-zhen,FANG Hong-xian.Irbesartan in treatment of early type 2 diabetic nephropathy[J].Journal of Tongji University(Medical Science),2013,34(5):98-101. [点击复制]
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| 摘要: |
| 目的观察厄贝沙坦治疗早期2型糖尿病肾病的临床效果。方法确诊为早期2型DN患者90例，随机分成对照组（45例）和观察组（45例）。对照组予传统常规治疗，控制血糖、血压（降压药排除ACEI及或ARB类）、血脂。观察组在对照组治疗的基础上加用或换用厄贝沙坦控制血压，3月后比较两组血压、血脂、血糖指标、尿微量白蛋白及血清胱抑素c的变化。结果两组在治疗前各项指标无明显差异，经过3个月的治疗，两组的血压，血糖（Glu、2hPG、HbAlC），血脂（HDL—C、TG、LDL—C），U—mAlb，CysC和血压较治疗前均有明显好转，差异有统计学意义（P〈0．01）；观察组的U．mAlb和CysC较对照组改善更明显（P〈0．05）。结论厄贝沙坦治疗早期糖尿病肾病，能有效减少U—mAlb及改善CysC水平，可能对延缓早期糖尿病肾脏病的进展有益。 |
| 关键词: 厄贝沙坦 糖尿病肾病 尿微量白蛋白 胱抑素c |
| DOI：10. 3969/j. issnl008 - 0392.2013. 05.023 |
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| Irbesartan in treatment of early type 2 diabetic nephropathy |
| YANG She-zhen,FANG Hong-xian |
| (Dept. of Endocrine, Haimen People＇s Hospital, Haimen 226100, Jiangsu Province, China; 2. Dept. of Pharmacy, Branch of Tongji Hospital, Tongji University, Shanghai 200092, China) |
| Abstract: |
| Objective To observe clinical effects of Irbesartan in treatment of early type 2 diabetic nephropathy. Methods Ninety patients with early type 2 diabetic nephropathy were enrolled in the study, including 45 patients treated with conventional medication （control group ） and another 45 patients treated with irbesartan （observation group）. The blood sugar, renal function index, urine albumin, plasma cystatin C were measured 3 months after treatment. Results Compare to control group, observation group had better clinical effect and laboratory results; there were significant differences in blood sugar （ Glu, 2hPG and HbA1 c ） and blood lipid （ HDL-C, TG, LDL-C ） levels, blood pressure control and kidney functions （U-mAlb and cystatin C） between two groups （all P 〈 0.05 ）. Conclusion Irbesartan has better clinical effect than conventional medication in treatment of early type 2 diabetic nephropathy. |
| Key words: Irbesartan diabetic nephropathy urine micro albumin cystatin C |
