胆囊切除术患者围术期抗生素合理应用的对比研究

Comparison of perioperative antibiotics administration in patients undergoing cholecystectomy before and after intervention

关键词:  围术期  胆囊切除术  合理用药

Key words:  perioperative period  cholecystectomy  rational drug administration

摘要:

目的 以胆囊切除术患者围术期抗生素应用为基点探讨抗生素合理应用的干预模式。方法回顾性分析我院2010年胆囊切除术患者围术期抗生素预防应用不足点,2012年采取一套新的教育管理办法管理围术期抗生素的应用。2013年行前瞻性研究并和2010年干预前进行比较。结果 2010年和2012年分别入选患者323人和428人,基线资料无差异,经上述措施干预后,患者总住院费用(中位数5834.90元、5022.52元)、抗生素费用(中位数674.6元、403.2元)、抗生素费用占总住院费用的比例(11.56%、9.05%)、住院天数[(8.87±6.62)d、(7.83±10.60)d]、抗生素合理比例(χ²=26.780,P=0.000)等改善明显。结论 本干预模式可促进胆囊切除术等疾病患者抗生素合理应用、下降单病种费用。

Abstract:

Objective To compare perioperative antibiotics administration in patients undergoing cholecystectomy before and after intervention program.Methods An education program of rational use of antibiotics was conducted in our hospital in 2012. The comparison of perioperative antibiotics administration in patients undergoing cholecystectomy was performed before and after the program implementation. Total 323 patients undergoing cholecystectomy in 2010 and 428 in 2013 were enrolled and the clinical data of two groups were comparable.Results After intervention, the mean of total hospital expenses (RMB 5834.90 Yuan vs 5022.52 Yuan), antibiotics expenses (RMB 674.6 Yuan vs 403.2 Yuan), ratio of antibiotics to total hospital expenses (11.56% vs 9.05%), length of hospital stay (8.87±6.62d vs 7.83±10.60d) and rate of rational antibiotics administration (23.2% vs 41.6%) were significantly improved (all P＜0.05).Conclusion The intervention program is practicable and effective for promoting rational perioperative antibiotic administration and decreasing medical expenses in patients undergoing cholecystectomy.