| 引用本文： |
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张中琳,赵伟,吴国亭.格列齐特对2型糖尿病GK大鼠离体心肌缺血预适应的影响[J].同济大学学报（医学版）,2015,36(5):39-42. [点击复制]
- ZHANG Zhong-lin,ZHAO Wei,WU Guo-ting.Effect of gliclazide on ischemic preconditioning in isolated rat heart[J].Journal of Tongji University(Medical Science),2015,36(5):39-42. [点击复制]
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| 摘要: |
| 目的 研究格列齐特对糖尿病GK大鼠离体心脏缺血预适应(ischemic preconditioning, IPC)保护作用的影响。方法 采用GK大鼠离体心脏Langendorff灌流模型,分为Wistar大鼠缺血预处理对照组(CON组)、GK大鼠缺血预适应保护组(GK组)、缺血预适应+格列齐特组(10μmol/L)(IPC+Glc组),每组8只。记录各组血流动力学指标,灌流后检测心肌梗死面积。结果 灌流30min时,与CON组相比,IPC+Glc组左心室功能有一定程度的改善(P＜0.05),IPC+Glc组和GK组心肌梗死面积无明显变化(P＞0.05)。结论 格列齐特未影响缺血预适应对心肌的保护作用。 |
| 关键词: 格列齐特 心肌缺血预适应 langendorff灌流 GK大鼠 |
| DOI：10.16118/j.1008-0392.2015.05.008 |
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| 投稿时间：2015-05-04 |
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| 基金项目:上海市科委科技攻关基金重点资助项目(04DZ19507) |
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| Effect of gliclazide on ischemic preconditioning in isolated rat heart |
| ZHANG Zhong-lin,ZHAO Wei,WU Guo-ting |
| (Dept.of Emergency, Tenth Hospital, Tongji University, Shanghai 200072,China;Dept.of Endocrinology, Tenth People's Hospital, Tongji University, Shanghai 200072, China) |
| Abstract: |
| Objective To investigate the effect of gliclazide on ischemic preconditioning(IPC) in isolated rat heart. Methods The hearts were isolated from male spontaneously diabetic goto-kakizaki(GK) rats and Wistar rats. The isolated hearts were perfused with Langendorff perfusion system, and randomly divided into three groups: Wistar ischemic preconditioning group(control group), GK ischemic preconditioning group(GK group); GK ischemic preconditioning+Gliclazide(10μmmol/L)(IPC+Glc group), with 8 hearts in each group. The hemodynamic indexes were recorded during the perfusion and the infarct size of isolated hearts was measured after perfusion. ResultsThe left ventricular function(dP/dt max and dP/dt min)of IPC+Glc group was significantly improved at 30min after perfusion compare with control group(P＜0.05). There was no significant difference in infarct size between IPC+Glc group and GK group. Conclusion The results show that gliclazide does not affect the myocardial protection of ischemic preconditioning in GK rats. |
| Key words: Gliclazide ischemic preconditioning langendorff GK rat |
