| 摘要: |
| 甲状腺癌是内分泌系统中最常见的恶性肿瘤,大部分患者在行甲状腺根治切除术后,联合I131放射治疗及药物化疗之后能够得到长期的生存率,但仍然有大约20%的患者,可能由于对化疗药物以及放射治疗不敏感,导致癌灶周围或者远处组织的转移。本文就甲状腺癌相关通路研究作一综述。 |
| 关键词: 甲状腺肿瘤 丝裂原活化蛋白激酶信号通路 磷脂酰肌醇激酶-蛋白激酶信号通路 |
| DOI：10.16118/j.1008-0392.2015.05.027 |
| 通信作者: |
| 投稿时间：2014-11-18 |
| 录用日期： |
| 基金项目:国家自然基金项目(81272240) |
|
| Research progress on signal pathways in thyroid cancer |
| LI Deng-feng,FANG Lin |
| (Dept. of Thyroid and Mammary Surgery, Tenth People's Hospital, Tongji University, Shanghai 200072, China) |
| Abstract: |
| Thyroid cancer is the most common endocrine malignancy. Most patients are managed successfully with a combination of radioiodine and levothyroxine treatment following complete thyroidectomy, while still nearly 20% patients will develop a local or distant recurrence, perhaps because of insensitivity to conventional chemo-and radio-therapy. This article reviews the recent progress on signal pathways in thyroid cancer. |
| Key words: thyroid carcinoma MAPK signal pathways PI3K-AKT signal pathways |
