| 引用本文： |
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曹伟丽,陈红.EMT患者血清和腹腔液中CA125、 VEGF、炎性细胞因子水平的变化及意义[J].同济大学学报（医学版）,2016,37(1):85-88, 92. [点击复制]
- CAO Wei-li,CHEN Hong.CA125 and cytokines levels in serum and peritoneal fluid of patients with endometriosis[J].Journal of Tongji University(Medical Science),2016,37(1):85-88, 92. [点击复制]
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| 摘要: |
| 目的探讨子宫内膜异位症(endometriosis, EMT)患者血清及腹腔液中CA125、VEGF及其炎性细胞因子IL-1β、IL-6、IL-8、TNF-α水平的变化及意义。方法 选择取2011年1月至2015年6月均经病理证实为EMT的109例患者为EMT组(r-AFS Ⅰ～Ⅱ期45例,Ⅲ～Ⅳ期64例),选择同期病理确诊为妇科良性病变患者79例为对照组。检测并分析EMT组、对照组患者血清及腹腔液中CA125、VEGF、IL-1β、IL-6、IL-8、TNF-α水平的变化。结果 EMT组患者血清和腹腔液中CA125、VEGF、IL-1β、IL-6、IL-8、TNF-α水平均高于对照组,差异均有统计学意义(P<0.05)；且随着r-AFS分期的增加,EMT Ⅲ～Ⅳ患者血清和腹腔液中CA125、VEGF、IL-1β、IL-6、IL-8、TNF-α水平高于Ⅰ～Ⅱ期患者,差异均有统计学意义(P<0.05)。结论 EMT患者血清和腹腔液中CA125、VEGF、IL-1β、IL-6、IL-8、TNF-α均明显高表达,且随着r-AFS分期的增加,患者血清和腹腔液中CA125、VEGF、IL-1β、IL-6、IL-8、TNF-α水平均提高。 |
| 关键词: 子宫内膜异位症 血清 腹腔液 |
| DOI：10.16118/j.1008-0392.2016.01.018 |
| 通信作者: |
| 投稿时间：2015-10-15 |
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| CA125 and cytokines levels in serum and peritoneal fluid of patients with endometriosis |
| CAO Wei-li,CHEN Hong |
| (Dept. of Obstetrics and Gynecology, Zhongnan Hospital, Wuhan University, Wuhan 430071, Hubei Province, China) |
| Abstract: |
| Objective To investigate the CA125 and cytokines levels in serum and peritoneal fluid of patients with endometriosis (EMT), and their clinical significance. Methods One hundred and nine EMT patients, including 45 cases of stage Ⅰ-Ⅱ and 64 cases of stage Ⅲ-Ⅳ were enrolled from 2011 January to 2015 August; 64 patients with benign gynecological diseases were also enrolled as control group. The levels of CA125, VEGF, IL-1β, IL-6, IL-8 and TNF-α in serum and peritoneal fluid were measured by ELISA method. ResultsThe levels of CA125, VEGF, IL-1β, IL-6, L-8 and TNF-α in serum and peritoneal fluid of EMT patients were significantly higher than those in control group(all P<0.05). The level of CA125, VEGF, IL-1β, IL-6, L-8 and TNF-α in serum and peritoneal fluid of EMT Ⅲ-Ⅳ group were significantly higher than those in EMT Ⅰ-Ⅱ group(all P<0.05). Conclusion The levels of CA125, VEGF, IL-1β, IL-6, L-8 and TNF-α in serum and peritoneal fluid are increased in EMT patients and the levels are increasing with the disease stages. |
| Key words: endometriosis serum peritoneal fluid |
