FEV3/FVC下降与早期气流受限的关系

Relationship between FEV3/FVC reduction and early airway obstruction in pulmonary function testing

关键词:  慢性阻塞性肺疾病  静态常规肺功能检测  早期气道阻塞

Key words:  chronic obstructive pulmonary disease  static routine pulmonary function test  early airway obstruction

摘要:

目的 探讨FEV₃/FVC与肺通气功能之间的关系及其在肺功能检查中的临床意义。 方法 根据常规肺功能检测(pulmonary function test, PFT)结果将受试的242例患者分为正常FEV₃/FVC和FEV₁/FVC组(A组,n=62)、仅FEV₃/FVC下降组(B组,n=40)及FEV₁/FVC下降组(C组,n=140)。观察三组受试者的肺功能指数变化。 结果 A组的年龄低于B组(P＜0.05)和C组(P＜0.01)。A组的BMI高于C组(P＜0.01)。肺功能检测中,A组FVC%pred及MEF50%pred高于B组(P＜0.05)。A组的FEV₁% pred、FEV₁/FVC、FEV₃/FVC、FEF25%～75%、FEF25%～75%pred、MEF25%及MEF25%pred均高于B组(P均＜0.01)。而PFT的其他指标如FVC、FEV₁、FEV₃、MEF75%、MEF75%pred及MEF50%与B组比较均无统计学差异。肺功能检测中A组的各项指标均高于C组(P均＜0.01)。肺功能检测中B组的各项指标均高于C组(P均＜0.01)。 结论 FEV₃/FVC单独下降可能提示早期的气道阻塞,FEV₃/FVC可能是判断早期气道阻塞更敏感的指标。

Abstract:

Objective To investigate the relationship between FEV₃/FVC in pulmonary function tests and the lung ventilation function. Methods Two hundred and forty two subjects underwent pulmonary function tests (PFT), the normal FEV₃/FVC and FEV₁/FVC was detected in 62 cases (group A), abnormal FEV₃/FVC in 40 cases (group B) and abnormal FEV₁/FVC in 140 cases (group C). Results The age of group A was lower than that of group B (P<0.05) and group C (P<0.01). BMI of group A was higher than that of group C (P<0.01). In PFT, FVC% pred and MEF50% pred of group A were higher than those of group B (P<0.05). FEV₁% pred, FEV₁/FVC, FEV₃/FVC, FEF25%～75%, FEF25%～75% pred, MEF25% and MEF25% pred of group A were higher than those of group B (P<0.01). While other indicators in PFT, including FVC, FEV₁, FEV₃, MEF75%, MEF75% pred and MEF50% in group A had no statistically differents with group B. In PFT, the indicators of group A were higher than those of group C (P<0.01), and the indicators of group B were higher than those of group C (P<0.01). Conclusion The subjects of airway obstruction present with a reduced FEV₃/FVC, which may be a more sensitive indicator for early airway obstruction.