| 摘要: |
| 目的 比较7种常见高危型HPV亚型感染与宫颈癌及高级别病变的相关性。方法 收集2014年1月至2016年10月在宁波市妇女儿童医院妇科接受宫颈组织学检查的1195例患者HPV16、18、31、33、35、52、58感染情况。采用Logistic回归方法分析上述各种高危型HPV亚型感染与宫颈癌及宫颈高级别病变的相关性。结果 在7种HPV亚型感染病例中，宫颈癌的检出率排序从高到低为： HPV18(5.78%)、HPV16(5.39%)、HPV58(1.71%)、HPV31(1.35%)、HPV52(0.39%)、HPV33(0%)、HPV35(0%)，宫颈高级别病变的检出率排序从高到低分别为： HPV33(48.04%)、HPV16(47.86%)、HPV58(29.56%)、HPV31(24.65%)、HPV18(23.31%)、HPV35(22.58%)、HPV52(21.26%)。HPV16型感染时患宫颈癌的风险最大(OR=3.831，P＜0.05)，HPV18型次之(OR=2.586，P＜0.05)；HPV16型感染时患宫颈高级别病变的风险也最大(OR=2.880，P＜0.05)，HPV33型次之(OR=2.531，P＜0.05)。结论 不同亚型的高危型HPV感染与宫颈癌及高级别病变的相关性不同；HPV16、18型感染与宫颈癌的相关性较大，HPV16、33型感染与宫颈高级别病变的相关性较大。 |
| 关键词: 高危型HPV 亚型 宫颈癌 宫颈高级别病变 |
| DOI：10.16118/j.1008-0392.2018.03.011 |
| 通信作者: |
| 投稿时间：2017-10-15 |
| 录用日期： |
| 基金项目:上海市科委项目(16411950200) |
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| Correlation between high-risk HPV subtypes infection and cervical cancer/high-grade cervical lesions |
| ZHANG Yi,WANG Jian-jun |
| (Dept. of Obstetrics and Gynecology, Tongji Hospital, Tongji University, Shanghai 200065, China; Dept. of Obstetrics and Gynecology, Ningbo Woman & Children's Hospital, Ningbo 315012, Zhejiang, China) |
| Abstract: |
| Objective To examine the correlation between high-risk HPV subtypes infection and cervical cancer/high-grade cervical lesions. Methods From January 2014 to October 2016, a total of 1195 HPV infected patients admitted at Ningbo Women's & Children's Hospital were enrolled in this study. The HPV subtypes involved in this study were HPV16, 18, 31, 33, 35, 52 and 58. All cases had a confirmed cervical pathological result. Univariate analysis and multivariate Logistic regression analysis was used to analyze the correlation between the high-risk HPV subtypes infection and cervical cancer/high-grade cervical lesions. Results The detection rates of cervical cancer in seven HPV subtypes infection cases were： HPV18 (5.78%), HPV16(5.39%), HPV58(1.71%), HPV31(1.35%), HPV52(0.39%), HPV33(0%) and HPV35(0%). The detection rates of high-grade cervical lesions in seven HPV subtypes infection cases were： HPV33(48.04%), HPV16(47.86%), HPV58(29.56%), HPV31(24.65%), HPV18(23.31%), HPV35(22.58%) and HPV52(21.26%). The risk of cervical cancer in the case of HPV16 infection was the greatest (OR=3.831，P＜0. 05), followed by HPV18 infection (OR=2.586，P＜0.05). The risk of high-grade cervical lesions in the case of HPV16 infection was still the greatest (OR=3.831，P＜0. 05), followed by HPV33 (OR=2.531，P＜0. 05). Conclusion The correlations between various high-risk HPV subtypes infection and cervical cancer/high-grade cervical lesions are different. HPV16 and 18 infection are likely to be associated with cervical cancer, while HPV16 and 33 infection are likely to be associated with high-grade cervical lesions. |
| Key words: high-risk HPV subtype cervical cancer high-grade cervical lesions |
