| 摘要: |
| 阿尔茨海默病（Alzheimer’s disease, AD）是一种以记忆功能损害为主，并伴有其他认知功能障碍的进展性神经退行性疾病，目前尚缺乏特异性的诊断方法和有效的治疗措施。现行的主要基于临床症状和认知功能量表检查的诊断方法很难早期诊断AD，也不易于将AD和与其具有相似临床症状的其他类型的神经退行性疾病区分开来。因此，AD的早期并精准的诊断成为近年来研究的热点。本文就AD的早期诊断进展进行综述，旨在为AD的早期精准诊断和治疗提供依据。 |
| 关键词: 阿尔茨海默病 诊断 神经成像 生物学标志物 |
| DOI：10.16118/j.1008-0392.2019.01.002 |
| 通信作者: |
| 投稿时间：2018-12-21 |
| 录用日期： |
| 基金项目:国家自然科学基金（81830059,81771889,81571655,81301200）；上海市申康医院发展中心计划（SHDC22015021） |
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| Research progress in early precise diagnosis of Alzheimer’s disease |
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| (Dept. of Medical Imaging, Tongji Hospital, Tongji University, Shanghai 200065, China) |
| Abstract: |
| Alzheimer’s disease(AD) is a progressive neurodegenerative disease with memory impairment and other cognitive dysfunction. Currently, there is no specific diagnostic method and effective Treatment measures. Current diagnostic methods based primarily on clinical symptoms and cognitive function scales are difficult to diagnose AD early, and it is not easy to distinguish AD from other types of neurodegenerative diseases with similar clinical symptoms. Therefore, the early and precise diagnosis of AD has become a hot topic in recent years. This article reviews the progress of early diagnosis of AD in order to provide a basis for early precise diagnosis and treatment of AD. |
| Key words: Alzheimer’s disease diagnosis neuroimaging biomarkers |
