| 引用本文： |
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王路鑫,黄 建,张杨杨,等.环状RNA在心血管系统中的表达与功能[J].同济大学学报（医学版）,2019,40(4):507-515. [点击复制]
- WANG Lu-xin,HUANG Jian,ZHANG Yang-yang,et al.Expression and function of circular RNAs in the cardiovascular system[J].Journal of Tongji University(Medical Science),2019,40(4):507-515. [点击复制]
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| 摘要: |
| 环状RNA（circular RNAs，circRNAs）是一类首尾通过共价键衔接构成封闭环状的单链RNA分子。与线性的RNA分子不同，它没有5′端帽子和3′ 端poly(A)尾巴，传统的RNA检测手段不易识别。高通量测序技术的应用及日益成熟使得人们逐渐认识到circRNAs在哺乳动物各组织大量、稳定存在，并在多种疾病的发生发展过程中起着重要的作用。本文就circRNAs的生物合成、功能和其在心血管疾病发生发展中的作用及机制进行综述。 |
| 关键词: 环状RNA 心血管疾病 生物合成 生物学标志物 |
| DOI：10.16118/j.1008-0392.2019.04.020 |
| 通信作者: |
| 投稿时间：2019-06-28 |
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| 基金项目:国家自然科学基金面上项目（81770397） |
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| Expression and function of circular RNAs in the cardiovascular system |
| WANG Lu-xin,HUANG Jian,ZHANG Yang-yang,CHEN Yi-Han |
| (Shanghai East Hospital of Clinical Medical College, Nanjing Medical University, Nanjing 210029, China; Key Laboratory of Arrhythmias of the Ministry of Education of China,Tongji University School of Medicine, Shanghai 200092, China) |
| Abstract: |
| Circular RNAs (circRNAs) are covalently closed, single-stranded RNA molecules produced by back-splicing from precursor mRNA (pre-mRNA). Unlike linear RNA molecules, circRNAs lack 5′ end caps and 3′ end poly (A) tails and are difficult to be detected by conventional methods of RNA analysis. Now, high-throughput sequencing has revealed the stable existence of abundant circRNAs in a variety of mammalian tissues, and it plays important roles in numerous diseases. Herein, we review the biogenesis and functions of circRNAs, with particular focus on their roles in cardiovascular diseases. |
| Key words: circular RNAs cardiovascular disease biogenesis biomarker |
