| 引用本文： |
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傅夏燕,陈其臻,尹喆,等.缺氧诱导因子-1调控卵泡发育的研究进展[J].同济大学学报（医学版）,2021,42(1):136-141. [点击复制]
- FU Xia-yan,CHEN Qi-zhen,YIN Zhe,et al.Research progress of hypoxia inducible factor-1 on follicular development[J].Journal of Tongji University(Medical Science),2021,42(1):136-141. [点击复制]
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| 摘要: |
| 缺氧诱导因子-1（hypoxia inducible factor-1, HIF-1）是一类介导缺氧适应性反应的转录因子，参与调节多种缺氧反应相关基因及其作用通路。卵泡发育的不同阶段及排卵过程通常处于缺氧的状态，HIF-1通过血管内皮细胞生长因子、促红细胞生成素、葡萄糖转运蛋白和糖酵解酶等靶基因，参与卵泡的发育调节。本文就HIF-1在卵泡发育以及排卵过程中的表达、作用机制等进行综述。 |
| 关键词: 缺氧 缺氧诱导因子-1 卵泡发育 颗粒细胞 排卵 |
| DOI：10.12289/j.issn.1008-0392.20066 |
| 通信作者: |
| 投稿时间：2020-02-17 |
| 录用日期： |
| 基金项目:上海市科学技术委员会女性生殖内分泌重点实验室项目(17DZ2273600);上海市胚胎源性疾病重点实验室项目(Shelab201903);上海市同济医院临床研究培育项目青年项目(ITJ(QN)1813) |
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| Research progress of hypoxia inducible factor-1 on follicular development |
| FU Xia-yan,CHEN Qi-zhen,YIN Zhe,WANG Yan-qiu |
| (Reproductive Medical Center, Tongji Hospital, Tongji University School of Medicine, Shanghai 200065, China; Tongji University School of Medicine, Shanghai 200092, China) |
| Abstract: |
| Hypoxia inducible factor-1 (HIF-1) is a kind of transcription factors that mediates hypoxia adaptive response to regulate the expression of many hypoxia response genes. Hypoxia induces the production of HIF-1, which participates in the regulation of follicular development through target genes such as vascular endothelial growth factor (VEGF) erythropoietin (EPO), glucose transporter and glycolytic enzyme. This article reviews the expression, mechanism and significance of HIF-1 in follicular development and ovulation. |
| Key words: hypoxia hypoxia inducible factor-1 follicular development granulosa cell ovulation |
