| 引用本文： |
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胡承平,陶凤芝,王 灿,等.星形胶质细胞在阿尔茨海默病中的研究进展[J].同济大学学报（医学版）,2023,44(5):740-746. [点击复制]
- HU Chengping,TAO Fengzhi,WANG Can,et al.The roles of astrocytes in Alzheimer’s disease[J].Journal of Tongji University(Medical Science),2023,44(5):740-746. [点击复制]
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| 摘要: |
| 中枢神经系统中，体积最大数量最多的星形胶质细胞(astrocyte, AS)具有营养支持、调节脑血流、维持脑稳态、分泌神经胶质、参与突触修剪、免疫等功能来维持脑内稳态。近年来研究发现，在阿尔茨海默病(Alzheimer’s disease, AD)病变过程中，AS不仅表现为生理功能的下降，还会促进Aβ沉积，Tau磷酸化，诱发炎症反应等，最终导致突触减少及神经元死亡。因此，本文对AS参与AD的有关机制进行系统综述。 |
| 关键词: 星形胶质细胞 阿尔茨海默病 轻度认知功能障碍 星形胶质细胞 炎症 |
| DOI：10.12289/j.issn.1008-0392.22434 |
| 通信作者: |
| 投稿时间：2022-11-06 |
| 基金项目:上海市浦东新区卫生系统领先人才培养计划（PWR12022-03）；上海市浦东新区卫生健康委员会医学临床高原学科建设项目(PWYgy2021-02)；上海市卫生健康委员会卫生行业临床研究专项（202240093） |
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| The roles of astrocytes in Alzheimer’s disease |
| HU Chengping,TAO Fengzhi,WANG Can,QIN Hongyun |
| (Department of Psychiatry, Shanghai Pudong New Area Mental Health Center, School of Medicine, Tongji University, Shanghai 200124, China) |
| Abstract: |
| Astrocytes, as the most abundant glial cells in the central nervous system(CNS), are essential for maintaining the homeostasis of CNS, with the functions of nutritional supporting, regulating cerebral blood flow, secreting neuroglia, and participating in synaptic pruning. In the process of Alzheimer’s disease(AD), astrocytes decline their physiological functions, and promote the deposition of Aβ, tau phosphorylation, inflammatory reactions, and eventually synaptic reduction and neuronal death. This article reviews the research advances on the roles of astrocytes in Alzheimer’s disease. |
| Key words: astrocyte Alzheimer’s disease mild cognitive impairment inflammation |
