| 引用本文： |
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谢金波,彭波.NCF2/p67phox在泛肿瘤中的表达调控及临床意义研究进展[J].同济大学学报（医学版）,2023,44(6):889-896. [点击复制]
- XIE Jinbo,PENG Bo.Expression and clinical significance of NCF2/p67phox in pan-tumor[J].Journal of Tongji University(Medical Science),2023,44(6):889-896. [点击复制]
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| 摘要: |
| NCF2基因编码的p67phox是一种典型的细胞质蛋白，广泛存在于哺乳动物的多种细胞。研究显示，NCF2/p67phox作为NADPH氧化酶的活化亚基，参与NADPH氧化酶/ROS介导的肿瘤生物学进程。本文从NCF2/p67phox的表达及调控、NADPH氧化酶在肿瘤中的作用、NCF2/p67phox在泛肿瘤的临床及基础研究进展等方面回顾文献，总结出NCF2/p67phox在肿瘤的热点研究方向。 |
| 关键词: NCF2/p67phox 癌基因 基因表达调控 泛肿瘤 |
| DOI：10.12289/j.issn.1008-0392.23097 |
| 通信作者: |
| 投稿时间：2023-05-12 |
| 录用日期： |
| 基金项目:国家自然科学基金面上项目（81870517）；安徽省高校优秀科研创新团队项目（2023AH010076） |
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| Expression and clinical significance of NCF2/p67phox in pan-tumor |
| XIE Jinbo,PENG Bo |
| (Department of Urology, The First Affiliated Hospital of Wannan Medical College(Yijishan Hospital of Wannan Medical College), Wuhu 241001, Anhui Province, China;Department of Urology, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University, Shanghai 200072, China) |
| Abstract: |
| P67phox encoded by NCF2 gene is a typical cytoplasmic protein widely present in various mammalian cells. Studies have shown that NCF2/p67phox, as the activator subunit of NADPH oxidase, participates in the biological process of tumors mediated by NADPH oxidase/ROS. This article reviews the research progress on NCF2/p67phox in pan-tumor, focusing on its expression in various tumors, and roles in regulating tumor biological behaviors through NADPH oxidase; and also discusses the hot research topics of NCF2/p67phox in tumors. |
| Key words: NCF2/p67phox oncogene gene expression regulation pan-tumor |
