引用本文: |
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李江涛,王慧芳,许晨,吴毅泰,马骏,$2.IgA肾病大鼠血清IgA-纤维连接蛋白的检测及意义[J].同济大学学报(医学版),2003,(5):391-394. [点击复制]
- .The Detection and Significance of Serum IgA-fibronectin on the Deposition of IgA in IgA Nephropathy[J].Journal of Tongji University(Medical Science),2003,(5):391-394. [点击复制]
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摘要: |
目的 检测IgA肾病大鼠血清IgA-纤维连接蛋白水平,探讨其在IgA肾小球系膜沉积中的作用。方法 肝叶切除后,尾静脉注射脂多糖,制作IgA肾病大鼠模型。应用ELISA法检测血清IgA-纤维连接蛋白聚合物水平,半定量法对系膜IgA免疫荧光强度评分,二者作相关性分析。结果 IgA肾病时,血清IgA-纤维连接蛋白聚合物水平升高,并与系膜IgA沉积呈正相关。结论 IgA肾病时,血清IgA-纤维连接蛋白聚合物水平是升高的,且可能是导致IgA系膜沉积的原因之一。 |
关键词: IgA肾病 IgA-纤维连接蛋白 脂多糖 大鼠 |
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修订日期:2003-02-25 |
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The Detection and Significance of Serum IgA-fibronectin on the Deposition of IgA in IgA Nephropathy |
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Abstract: |
Objective To investigate the role of serum Ig A-fibronectin in the deposition of IgA in mesangium. Methods IgA nephropathy rats were made by hepatotomy and intravenous injection of LPS.The serum IgA-fibronectin were detected by an ELIS A method and usin |
Key words: IgA nephropathy,IgA-fibronectin,LPS,rats |