| 引用本文： |
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李从烨,高成金,张翔宇.p38信号通路在呼吸机相关性肺损伤中的作用[J].同济大学学报（医学版）,2014,35(4):126-128. [点击复制]
- LI Cong-ye,GAO Cheng-jin,ZHANG Xiang-yu.p38MAPK signaling pathway is involved in ventilator-induced lung injury[J].Journal of Tongji University(Medical Science),2014,35(4):126-128. [点击复制]
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| 摘要: |
| 呼吸机相关性肺损伤（ventilator-induced lung injury,VILI）是由机械通气产生的严重并发症,VILI的类型主要包括：气压伤（baratrauma）、容积伤（volutrauma）、肺萎陷伤（atelectrauma）、生物伤（biotrauma）,目前临床上仍无有效的治疗策略。丝裂原活化蛋白激酶家族可以在一系列细胞外刺激下参与细胞应答,在哺乳动物中,已经发现了ERKs（extracellular signal-regulated kinase）、JNK/SAPK（c-jun N-terminal/stress-activated protein kinase）、ERK5/BMK1（ERK/big MAP kinase 1）以及p38四个亚家族。随着对VILI的不断深入研究,p38通路被认为参与了VILI的发生机制,深入研究p38信号通路在VILI中的作用,可为临床提供新的治疗靶点。 |
| 关键词: p38M APK 信号通路 呼吸机相关性肺损伤 |
| DOI：10.3969/j.issn1008-0392.2014.04.028 |
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| 录用日期： |
| 基金项目:国家自然科学基金（81000024） |
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| p38MAPK signaling pathway is involved in ventilator-induced lung injury |
| LI Cong-ye1,2,GAO Cheng-jin1,ZHANG Xiang-yu1 |
| (1. Dpet. of Emergency, Tenth People＇s Hospital, Tongji University, Shanghai 200072, China; 2. Dept. of Intensive Care Unit, Tenth People＇s Hospital, Tongji University, Shanghai 200072, China) |
| Abstract: |
| Ventilator-induced lung injury （VILI） is one of the most serious complications of mechanical ventilation. There are four types of VILI, namely baratrauma, volutrauma, ateletrauma and biotrauma. Members of mitogen-activated protein kinase family participate in cellular responses to a wide range of extracellular stimuli. Four subfamilies of MAPkinase, ERK, JNK/SAPK, ERK5/ BMKI and p38 have been identified in mammalian cells. The p38 MAPK （mitogen-activated protein kinase） signaling pathway is considered one of the mechanisms of VILI. In this article we review the involvement of p38 MAPK in VILI, which may provide a novel target for prevention and treatment of VILI. |
| Key words: p38MAPK signaling pathway ventilator-induced lung injury |
