| 引用本文： |
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唐瑾,郭忠良.全氟化碳在治疗ALI/ARDS时对促炎因子影响的研究进展[J].同济大学学报（医学版）,2014,35(4):129-132. [点击复制]
- TANG Jin,GUO Zhong-liang.Research advances in effect of perfluorocarbons on pro-inflammatory cytokines in treatment of ALI/ARDS[J].Journal of Tongji University(Medical Science),2014,35(4):129-132. [点击复制]
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| 摘要: |
| 以全氟化碳（Perfluorocarbons,PFC）为通气媒介的部分液体通气技术是近年来新兴的治疗ALI/ARDS的技术,其中对促炎因子的抑制作用可能是保护机制之一。虽然目前有关PFC抗炎的分子机制尚未完全阐明,但细胞和动物实验充分证明了PFC可以拮抗ALI/ARDS的炎症反应,可临床研究却令人失望。本研究就近年来全氟化碳对促炎因子TNF-α、IL-1、IL-6、IL-8影响的相关研究进展进行综述。 |
| 关键词: 全氟化碳 部分液体通气 急性肺损伤 促炎因子 |
| DOI：10.3969/j.issn1008-0392.2014.04.029 |
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| 录用日期： |
| 基金项目:国家自然科学基金面上项目（81270134）; 上海市自然科学基金（11ZR1429700） |
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| Research advances in effect of perfluorocarbons on pro-inflammatory cytokines in treatment of ALI/ARDS |
| TANG Jin1,GUO Zhong-liang2 |
| (1. Dept. of Central ICU, Shanghai 200120, China;;2. Dept. of Respiratory Medicine, East Hospital, Tongji University, Shanghai 200120, China) |
| Abstract: |
| Perfluorocarbones （PFC）-based partial liquid ventilation （PLV） is of interest for the treatment of acute lung injury/acute respiratory distress syndrome （ALI/ARDS）. Cellular and animal studies have revealed that PFC suppresses anti-inflanunatory response, which may contribute to the protective mechanisms in ALI/ARDS. But clinical trials did not show a satisfactory outcome of PLV in ALI/ARDS patients. This article reviews the effects of PFC on decrease of pro-inflammatory cytokines TNF-α, IL-1, IL-6 and IL-8 in treatment of ALI/ARDS. |
| Key words: perfluorocarbons partial liquid ventilation acute lung injury pro-inflammatory cytokines |
