| 引用本文： |
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王佳怡,庄少伟.外泌体在急性心肌梗死诊疗中的研究进展[J].同济大学学报（医学版）,2021,42(6):860-866. [点击复制]
- WANG Jia-yi,ZHUANG Shao-wei.Research progress of exosomes in acute myocardial infarction[J].Journal of Tongji University(Medical Science),2021,42(6):860-866. [点击复制]
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| 摘要: |
| 急性心肌梗死(acute myocardial infarction, AMI)是冠状动脉突发的、持续性缺血缺氧导致的心肌损伤过程，众多证据表明外泌体在AMI过程中发挥重要的作用。外泌体作为细胞外囊泡的一员，通过多种信息分子传递细胞间信号，从而介导多种病理生理过程。本文以外泌体内不同种信号传递物质作为切入点，探讨外泌体在对AMI诊治过程中的影响，并讨论其在AMI诊疗过程中的展望。 |
| 关键词: 急性心肌梗死 外泌体 细胞间信号传递 生物标志物 |
| DOI：10.12289/j.issn.1008-0932.21205 |
| 通信作者: |
| 投稿时间：2021-05-17 |
| 录用日期： |
| 基金项目:上海市浦东新区科技发展基金民生科研专项资金医疗卫生项目(PKJ2018-Y15);上海市卫生健康委员会科学研究项目 (201940461) |
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| Research progress of exosomes in acute myocardial infarction |
| WANG Jia-yi,ZHUANG Shao-wei |
| (Dept. of Cardiology, The Seventh Peoples Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200137, China) |
| Abstract: |
| Acute myocardial infarction is the myocardial damage caused by coronary ischemia and hypoxia. A lot of research evidence have shown that exosomes play an important role in the development of acute myocardial infarction. As a member of extracellular vesicles, exosomes carry information molecules that transmit intercellular signals and mediate a variety of pathophysiological processes. This article reviews the different kinds of signal transmitting proteins inside the exosomes, and their effects on the process of acute myocardial infarction; also discuss the potential application of exosomes in the diagnosis and treatment of acute myocardial infarction. |
| Key words: acute myocardial infarction exosome intercellular signal transmission biomarker |
