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  • 秦黎黎,潘蕾宇,崔柠薪,等.3D生物打印技术在骨及软骨再生修复中的研究进展[J].同济大学学报(医学版),2024,45(2):281-289.    [点击复制]
  • QIN Lili,PAN Leiyu,CUI Ningxin,et al.Research Progress of 3D bio-printing technique in osteochondral regeneration and repair[J].同济大学学报(医学版),2024,45(2):281-289.   [点击复制]
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3D生物打印技术在骨及软骨再生修复中的研究进展
秦黎黎,潘蕾宇,崔柠薪,卢天凤
0
(同济大学体育教学部运动与健康研究中心,上海200092)
摘要:
3D生物打印是一种将活细胞、生物材料、药物、生长因子和基因逐层进行空间排列的技术。该技术在骨及软骨修复领域的应用取得了显著的进展,可以解决传统手术方法存在的问题,如创伤大、周期长、难度高、并发症多、生物活性和生物相容性不足等,潜力巨大。本文概述了3D生物打印技术如何通过使用生物可降解材料和细胞制造出具有生物活性和生物相容性的骨和软骨组织,旨在为后续研究提供理论基础。
关键词:  3D生物打印  骨缺损  软骨缺损  再生  组织修复
DOI:10.12289/j.issn.2097-4345.23121
投稿时间:2023-04-16
基金项目:国家自然科学基金(31771313)
Research Progress of 3D bio-printing technique in osteochondral regeneration and repair
QIN Lili,PAN Leiyu,CUI Ningxin,LU Tianfeng
(Sports And Health Research Center, Faculty of Physical education, Tongji University, Shanghai 200092, China)
Abstract:
The 3D bio-printing is a technique that spatially arranges living cells, biomaterials, drugs, growth factors and genes by layer. The application of 3D bio-printing has made remarkable progress in the field of bone and cartilage repair. Compared to traditional surgical treatment, it has great advantages of less tissue trauma, shorter time consuming and fewer complications, as well as higher bioactivity and higher biocompatibility. This article gives an account of how 3D bioprinting technique produces bioactive and biocompatible bone and cartilage tissue by using biodegradable materials and cells, to provide reference for its clinical application.
Key words:  three-dimensional bioprinting  bone defect  cartilage defect  regeneration  tissue repair

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