| 引用本文： |
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梁家琪,申朝阳,李 澳,等.IL-22与卵巢慢性炎症性疾病关系的研究进展[J].同济大学学报（医学版）,2025,46(1):132-138. [点击复制]
- LIANG Jiaqi,SHEN Zhaoyang,LI Ao,et al.Research progress on the correlation between IL-22 and chronic inflammatory diseases of ovary[J].Journal of Tongji University(Medical Science),2025,46(1):132-138. [点击复制]
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| 摘要: |
| IL-22作为炎症因子，在炎症调控过程中发挥重要作用。在肾脏、肝脏等部位慢性炎症性疾病中，IL-22通过缓解纤维化、氧化应激过程，发挥抗炎作用，延缓疾病进展，保护器官功能。本文从IL-22结构特点及其在慢性炎症中作用等方面，综述IL-22作为关键细胞因子在卵巢慢性炎症性疾病中的作用，以期为保护卵巢功能，提高生育力找到新的治疗靶点。 |
| 关键词: 白细胞介素-22 氧化应激 炎症调控 卵巢慢性炎症 |
| DOI：10.12289/j.issn.2097-4345.24223 |
| 通信作者: |
| 投稿时间：2024-05-27 |
| 录用日期：2024-11-01 |
| 基金项目:上海市科委多中心联合项目(202411)；上海市嘉定区卫生健康委科研项目(2022-KY-12) |
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| Research progress on the correlation between IL-22 and chronic inflammatory diseases of ovary |
| LIANG Jiaqi,SHEN Zhaoyang,LI Ao,ZHOU Xuan,WANG Yanqiu |
| (Center for Reproductive Medicine, Tongji Hospital, School of Medicine, Tongji University, Shanghai 200065, China) |
| Abstract: |
| Interleukin-22(IL-22), as an inflammatory factor, plays an important role in the regulation of inflammation. In chronic inflammatory diseases of organs such as kidney and liver, IL-22 plays an anti-inflammatory role by alleviating fibrosis and oxidative stress, delaying disease progression and protecting organ function. This article reviews the key role of IL-22 as a key cytokine in chronic inflammatory diseases of the ovary from the aspects of its structural characteristics and its role in chronic inflammation, in order to find a new therapeutic target for protecting ovarian function and improving fertility. |
| Key words: interleukin-22 oxidative stress inflammation regulation chronic inflammation of ovary |
