| 引用本文： |
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刘鹏,王从容.间充质干细胞治疗2型糖尿病的临床研究现状[J].同济大学学报（医学版）,2021,42(2):167-171. [点击复制]
- LIU Peng,WANG Cong-rong.Therapeutic potential of mesenchymal stem cells in patients with type 2 diabetes mellitus[J].Journal of Tongji University(Medical Science),2021,42(2):167-171. [点击复制]
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| 摘要: |
| 2型糖尿病的发生、发展与胰岛β细胞功能缺陷、胰岛素抵抗密切相关，自身免疫系统介导的炎症反应在其中发挥重要作用。近年来，间充质干细胞（mesenchymal stem cells, MSCs）移植成为治疗糖尿病的研究热点。关于干细胞移植治疗2型糖尿病的临床有效性和安全性，目前仍存在争议。本文综述国内外开展的MSCs治疗糖尿病及其并发症间的研究现状，总结研究中存在的相关问题和经验教训，为后续临床治疗提供新思路。 |
| 关键词: 2型糖尿病 间充质干细胞 临床研究 |
| DOI：10.12289/j.issn.1008-0392.20517 |
| 通信作者: |
| 投稿时间：2020-12-02 |
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| Therapeutic potential of mesenchymal stem cells in patients with type 2 diabetes mellitus |
| LIU Peng,WANG Cong-rong |
| (Dept. of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth Peoples Hospital,;Translational Medical Center for Stem Cell Therapy, Shanghai East Hospital,) |
| Abstract: |
| The pathogenesis and development of type 2 diabetes mellitus（T2DM) are closely related to pancreatic β-cells functional deficiencies and insulin resistance. The inflammatory response mediated by the autoimmune system plays an important role in this process. In recent years, mesenchymal stem cells（MSCs） transplantation has become a research hotspot in the treatment of diabetes. However, there are still controversies about the clinical effectiveness and safety of stem cell transplantation in the treatment of type 2 diabetes. This article reviews the current status of research in the field of MSCs therapy for diabetes and its complications at home and abroad, and aims to summarize the relevant problems and lessons learned and to provide new ideas for its further clinical application. |
| Key words: type 2 diabetes mellitus mesenchymal stem cells clinical research |
